29 March, 2021

Appointment of Chief Financial Officer

e-therapeutics plc today announces the appointment of Dr Karl Keegan as Chief Financial Officer ("CFO") effective immediately. The CFO role will be a non-board position.

Dr Keegan brings a depth of capital market and strategic financing experience with over 20 years' experience in the pharmaceutical and biotech industries. After working in academia and large pharma, Karl became a highly rated sell-side analyst at a number of investment banks. Since 2009, he has held senior executive roles in private and public companies, most recently as Chief Executive Officer of privately held Hox Therapeutics Limited.

Karl received his BSc in Pharmacology from University College Dublin, MPhil and PhD degrees from the University of Cambridge and his MSc (Finance) from London Business School.

I am delighted to be joining the e-therapeutics team at such a pivotal time for the Company. The Company has built an impressive computational biology drug discovery platform and clinically validated RNA interference drug modality.

Dr Keegan

Chief Financial Officer

We are delighted to welcome Karl to e-therapeutics at this point in the Company's evolution. The combination of his industry and financial sector expertise will be a major addition to the team.

Ali Mortazavi

Chief Executive Officer