Our Assets

NDD-derived assets: current self-funded programmes

We are currently focusing our internal resources on two self-funded NDD-derived immuno-oncology programmes. Click on the projects below to read more.

Networks
Hit Discovery
Hit to Lead
Lead Optimisation
Tryptophan catabolism
Immune checkpoint modulation

Examples of partner-ready programmes

Our NDD platform can go from a biological concept to hits in months and has been validated across 12 diverse areas of biology. Positive data has been generated in the following programmes that are ready to be progressed to the next stage in collaboration with the right partner. Click on the projects below to read more.

Networks
Hit Discovery
Hit to Lead
Lead Optimisation
Hedgehog pathway inhibition
TNFα production
Axonal degeneration
Pro-coagulant
Immune receptor ligand (“IRL”) modulation
Anti-influenza

Examples of projects in new areas

We have undertaken network analysis in the following commercially relevant areas offering an interesting potential for progressing asset discovery programmes with the right partner. Click on the projects below to read more.

Networks
Hit Discovery
Hit to Lead
Lead Optimisation
Idiopathic pulmonary fibrosis (“IPF”)
Innate immunity – STING
Tumour microenvironment - Macrophage polarisation
Tumour microenvironment - T reg cell function
Neurodegeneration – Proteostasis

Downloads

Hedgehog pathway inhibition

Download

TNF alpha production

Download

Axonal degeneration

Download

Anti-influenza

Download

Idiopathic pulmonary fibrosis ("IPF")

Download

Innate immunity - STING

Download

TME - Macrophage polarisation

Download

TME - Treg cell function

Download

Neurodegeneration - Proteostasis

Download