Cells contain many different proteins. These proteins interact to form complex networks. These networks carry out all the varied aspects of normal function. Alterations to them are often a defining feature of disease.
e-Therapeutics’ discovery processes begin by identifying the specific physiology that we wish to affect in a target disease. The proteins that participate in the networks that mediate this specific physiology are then identified, and the networks in which they function are mapped. This complex network of proteins is then analysed to identify multiple intervention points that, if impacted simultaneously, will disrupt the disease-related network.
We then seek drug molecules with the best overall impact in the disease-related network. This search process takes account of the chemical biology profile of the molecules. This approach, sometimes called Network Pharmacology, differs from ‘conventional’ drug discovery, which is typically based on high-affinity inhibition of a single protein ‘target’. We believe that, by accounting more realistically for both the complexity of disease at the outset and for the many effects of the presence of a drug molecule in the body, our approach has the potential to discover more effective drug treatments.