Network pharmacology drug discovery

In all of life that is relevant to disease, there are hundreds of thousands of proteins. Every drug compound binds in varying degrees to many different proteins, and can affect very many proteins in other ways, such as through changing their expression, or phosphorylation state.

The huge variety of possible protein targets, and the large variety of patterns of possible effects on proteins create an enormous range of possible interactions between a drug molecule and any biological system. For this fundamental reason, the biological effects of a molecule's interactions with pathogenic, pathological and normal cells have been very difficult to predict.

e-Therapeutics proprietary network pharmacology platform calculates the net biological effect of interference with one or many proteins in a cell. These  fast processes have been shown to predict biological effects accurately.

In drug discovery, e-Therapeutics uses these capabilities to search for new drugs across several  therapeutic areas. Our current effort is focused particularly in cancer and degenerative diseases of the nervous system. Drugs discovered previously for cancer, infectious disease and depression have now progressed into our clinical development pipeline.